Rapamycin also inhibited the multiplication of colony-forming cells in suspension cultures containing IL-3 plus interleukin-1 (IL-1) or interleukin-11 (IL-11) plus KL.read more...

FTY720(fingolimod) is a potent sphingosine-1-phosphate (S1P) receptors agonist with IC50 of 0.137, 10.98 nM for (S)- and (R)- FTY720-phosphate, respectively and reverses the effects of BCR-ABL kinase.know more...

Perifosine has a lower gastrointestinal toxicity profile than the related agent miltefosine.PLX4032 is a highly selective inhibitor of BRAF kinase activity, with an IC50 of 44 nmol/L against V600E-mutant BRAF.more details...

 Poly (ADP-ribose) polymerase (PARP inhibitor) comprises 17 members (10 putative).PARP inhibitors are essential in the repair of single-stranded breaks in DNA.more info...

RAD001 inhibits the proliferation of a wide variety of human solid tumor cell lines both in vitro in cell culture and in vivo in animal xenograft models.know better...

A phase I/II study was done to determine safety and efficacy of Everolimus in patients with relapsed or refractory hematologic malignancies.

At 4.4 μM imatinib mesylate, the amount of activated NK-kB was reduced to 58.7% and decreased to 38.4% at 17.6 μM.learn more...

Tosedostat (formerly CHR-2797) is an aminopeptidase inhibitor with IC50 of 100, 150, 220, >1000, >5000, >10000 and >30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA4 hydrolase and MetAP2, respectively.Know more...

Browse Tyrosine Kinase Inhibitors By Pharmacological Activity.want to know more about Kinase Inhibitor?

MLN-2238 is a potent reversible and specific β5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM.

IC-87114 was the first isoform-selective PI3K inhibitor : p110δ(IC50 = 0.13 μM) vs. p110α(IC50 = 200 μM), p110β(IC50 = 16 μM) and p110γ(IC50 = 61 μM).learn more about PI3K inhibitors?

AT7867 is a potent and oral AKT inhibitor and p70 S6 kinase inhibitor with an IC50 of 17 nM.a lot of about AKT inhibitors .

HDAC inhibitor with IC50 of 27 nM.more about HDAC inhibitors

mTOR inhibitor with an IC50 of 0.63 nM.Know more about mTOR inhibitors

Chrysophanic acid (Chrysophanol) is a EGFR inhibitor/mTOR pathway inhibitor.

A selective Hsp90 inhibitor with a GI50 of 53 nM.JNJ-38877605 is a c-MET inhibitor with an IC50 of 4 nM.

keywords:

c-met inhibitors,hsp90 inhibitors, egfr inhibitors,mek inhibitor,mek inhibitors